Decreased Total Antioxidant Capacity in Plasma, but Not Tissue, in Experimental Colitis
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Data
2009-04-01
Autores
Bregano, Jose Wander
Dichi, Jane Bandeira
Barbosa, Decio Sabbatini
El Kadri, Mirian Zebian
Matsuo, Tiemi
Rodrigues, Maria Aparecida [UNESP]
Cecchini, Rubens
Dichi, Isaias
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Título de Volume
Editor
Springer
Resumo
The aim of the present work was to compare colonic mucosa and plasmatic oxidative stress measured concomitantly and with different degrees of injury in rats with colitis induced by trinitrobenzene sulfonic acid. Three groups were studied: control group, colitis group, and colitis exacerbated by diclofenac. Enzymatic markers of colon injury showed enhanced activity in both groups with colitis. The colitis group treated with diclofenac presented higher colonic damage score than the other groups. In both groups with colitis, higher values of tert butyl hydroperoxide-initiated-chemiluminescence and thiobarbituric acid-reactive substances in tissue and decreased total radical-trapping antioxidant potential (TRAP) levels in plasma were found. In conclusion, independently of the degree of colonic mucosa injury and inflammation, oxidative stress in tissue occurs as a consequence of pro-oxidants increase, and is not explained by a reduction of antioxidant defenses. In both conditions, TRAP determination decreases in plasma, but not in tissue.
Descrição
Palavras-chave
Experimental colitis, Trinitrobenzene sulfonic acid, Nonsteroidal anti-inflammatory drugs, Oxidative stress, Free radicals
Como citar
Digestive Diseases and Sciences. Dordrecht: Springer, v. 54, n. 4, p. 751-757, 2009.