Publicação: K-ATP(+) Channels-Independent Analgesic Action of Crotalus durissus cumanensis venom
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Natural Products Inc
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
The effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 mu g/kg) produced an antinociceptive effect during phase 2 in the formalin test. The effect of CDCM (200 mu g/kg) was unaffected by the ATP-sensitive K+ channel blocker glibenclamide (2 mg/kg). These results suggest that CDCM is effective against acute pain. However, the ATP-sensitive K+ channels pathway is not contributable to the antinoeiceptive mechanism of CDCM.
Descrição
Palavras-chave
Crotalus durissus cumanensis venom, nociception, glibenclamide
Idioma
Inglês
Como citar
Natural Product Communications. Westerville: Natural Products Inc, v. 5, n. 7, p. 1103-1106, 2010.
