Treatment of Pythiosis in Equine Limbs Using Intravenous Regional Perfusion of Amphotericin B
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2012-08-01
Autores
Doria, Renata G. S.
Freitas, Silvio H.
Linardi, Renata L.
Mendonca, Fabio de Souza
Arruda, Laura P.
Boabaid, Fabiana M.
Valadao, Carlos A. A. [UNESP]
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Wiley-Blackwell
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Objective To evaluate the effects of intravenous regional limb perfusion (IRLP) administration of amphotericin B in horses to treat pythiosis after surgical excision and thermocautery. Study Design Case series. Animals Horses (n = 12) with Pythium insidiosum infection of the distal aspect of the thoracic or pelvic limbs. Methods After surgical excision of granulation tissue and thermocautery, 50 mg amphotericin B was administered by IRLP through a catheter placed in a superficial vein of the affected limb next to the lesion after placing a tourniquet above the injection site. The lesions and locomotor system were evaluated before treatment and at 7, 14, 21, 28, 35, and 60 days. Results Ninety-two percent of horses treated with amphotericin B had complete lesion resolution 35 or 60 days after 1 or 2 IRLP treatments, respectively. IRLP induced limb edema and pain during regional palpation in 42%, and inflammation of the injection site in 33% of horses; however these signs resolved after 14 days. Conclusions IRLP administration of amphotericin B was effective for treating pythiosis in equine limbs, resolving infection with manageable side effects.
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Veterinary Surgery. Hoboken: Wiley-blackwell, v. 41, n. 6, p. 759-765, 2012.