Propolis Standardized Extract (EPP-AF (R)), an Innovative Chemically and Biologically Reproducible Pharmaceutical Compound for Treating Wounds
Carregando...
Data
2012-01-01
Autores
Berretta, Andresa Aparecida
Nascimento, Andresa Piacezzi
Pires Bueno, Paula Carolina [UNESP]
Lima Leite Vaz, Mirela Mara de Oliveira
Marchetti, Juliana Maldonado
Título da Revista
ISSN da Revista
Título de Volume
Editor
Ivyspring Int Publ
Resumo
The aim of this study was to develop a formulation, containing the propolis standardized extract (EPP-AF (R)), which can assist in the healing of skin lesions. To achieve this objective the antimicrobial activity and chemical composition of the propolis extract was determined. The final product was subjected to in vitro and in vivo pre-clinical evaluation. The broth macrodi-lution method was used to determine the antimicrobial activity of the extracts and formulations against the microorganisms most commonly found in burns, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Staphylococcus epidermidis. Wistar rats with puncture wounded skin were used to evaluate the wound healing properties of propolis. The results of chemical and biological characterization demonstrated the batch-to-batch reproducibility of the standardized extract which is an unprecedented result. The antimicrobial and wound healing activity of the pharmaceutical studied showed the best results when samples contain 3.6% propolis, suggesting that this is the most promising composition.
Descrição
Palavras-chave
propolis, EPP-AF (R), antimicrobial activity, wound healing, pharmaceutics, reproducibility
Como citar
International Journal of Biological Sciences. Lake Haven: Ivyspring Int Publ, v. 8, n. 4, p. 512-521, 2012.