Publication: ANALISE FAMILIAL DO COMPORTAMENTO IN VITRO DOS MACROFAGOS HUMANOS FRENTE AO MYCOBACTERIUM LEPRAE
Loading...
Date
Authors
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Type
Article
Access right
Acesso restrito
Abstract
The lysogenic capacity of human macrophages facing M. leprae in vitro may be dependent on an important genetic component. Although the familial aggregation of the trait is demonstrated, this is a necessary but not sufficient condition to prove genetic influence. The data do not fit some simple genetic models (autosomal dominant or incompletely dominant gene; dominant or recessive sex-linked gene). The results obtained are consistent with the hypothesis that the macrophages' lysogenic capacity is mainly due to a major gene with variable expressivity. This hypothesis may be too simple to account for the whole variability detected and therefore must be considered a working hypothesis.
Description
Keywords
genetics, heredity, human, leprosy, macrophage, mycobacterium leprae, blood, in vitro study, Mycobacterium leprae, phenotype, physiology, English Abstract, Human, In Vitro, Leprosy, Macrophages, Phenotype, Support, Non-U.S. Gov't
Language
Portuguese
Citation
Hansenologia Internationalis, v. 8, n. 2, p. 91-100, 1983.
