Publicação: ANALISE FAMILIAL DO COMPORTAMENTO IN VITRO DOS MACROFAGOS HUMANOS FRENTE AO MYCOBACTERIUM LEPRAE
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The lysogenic capacity of human macrophages facing M. leprae in vitro may be dependent on an important genetic component. Although the familial aggregation of the trait is demonstrated, this is a necessary but not sufficient condition to prove genetic influence. The data do not fit some simple genetic models (autosomal dominant or incompletely dominant gene; dominant or recessive sex-linked gene). The results obtained are consistent with the hypothesis that the macrophages' lysogenic capacity is mainly due to a major gene with variable expressivity. This hypothesis may be too simple to account for the whole variability detected and therefore must be considered a working hypothesis.
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genetics, heredity, human, leprosy, macrophage, mycobacterium leprae, blood, in vitro study, Mycobacterium leprae, phenotype, physiology, English Abstract, Human, In Vitro, Leprosy, Macrophages, Phenotype, Support, Non-U.S. Gov't
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Português
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Hansenologia Internationalis, v. 8, n. 2, p. 91-100, 1983.
