Publicação: Effects of the application of α1- and α2-adrenoceptor agonists and antagonists into the ventromedial hypothalamus on the sodium and potassium renal excretion
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The effects of sodium and potassium excretion after intrahypothalamic administration of two α-adrenoceptor agonists and the effect of α-adrenoceptor antagonists were studied in groups of rats. Prazosin was equally effective at blocking the natriuretic and kaliuretic responses to the α1-adrenoceptor agonist phenylephrine and the mixed α1/α2-adrenoceptor agonist noradrenaline, while yohimbine which acts preferentially on α2-adrenoceptors was effective in potentiating these responses. These results suggest the presence of two types of α-adrenoceptors for the modulation of ventromedial hypothalamic pathways that interfere with the regulation of the two cations: stimulation of α1-adrenoceptors facilitates, while stimulation of α2-adrenoceptors inhibits the excretion of the ions.
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alpha 1 adrenergic receptor, alpha 2 adrenergic receptor, alpha adrenergic receptor stimulating agent, noradrenalin, phenylephrine, prazosin, yohimbine, animal experiment, central nervous system, kidney, nonhuman, potassium urine level, rat, sodium urine level, zona incerta, Adrenergic alpha-Agonists, Adrenergic alpha-Antagonists, Animal, Dogs, Dose-Response Relationship, Drug, Hypothalamus, Middle, Norepinephrine, Phenylephrine, Potassium, Prazosin, Rabbits, Rats, Sodium, Support, Non-U.S. Gov't, Yohimbine
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Pharmacology, v. 28, n. 4, p. 228-234, 1984.
