Publicação: The development of a febrile response to pyrogen in the thyroid-deficient rabbit
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1987-01-01
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The development of the febrile response to E. coli lipopolysaccharide (1.5 μg/kg, i.v.) in thyroid-deficient rabbits has been studied. Twenty-eight New Zealand White rabbits weighing 2.1-2.3 kg were used. Hypothyroidism was induced by treatment with propylthiouracil (100 or 200 mg/kg body wt./15 days). Thyroid-deficient animals showed a reduction in the febrile response to lipopolysaccharide, but the effect was significantly different (p<0.01) from the control only for rabbits treated with 200 mg/kg of propylthiouracil. Propranolol (2 mg/kg, i.p.) given 30 min before lipopolysaccharide also reduced (p<0.01) the fever response in control rabbits. The results of this experiment are consistent with the hypothesis that the reduction in the febrile response of thyroid-deficient rabbits is due to the reduced number of β-adrenergic receptors, or to a change in the availability of neurotransmitter in thermogenically active tissues, such as brown fat.
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escherichia coli endotoxin, propranolol, propylthiouracil, animal experiment, central nervous system, dose time effect relation, drug inhibition, endocrine system, fever, hypothyroidism, intraperitoneal drug administration, intravenous drug administration, nonhuman, oral drug administration, pharmacokinetics, rabbit, therapy, thyroidectomy, Animal, Body Temperature, Fever, Hypothyroidism, Lipopolysaccharides, Male, Propranolol, Propylthiouracil, Pyrogens, Rabbits, Support, Non-U.S. Gov't
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Inglês
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Canadian Journal of Physiology and Pharmacology, v. 65, n. 6, p. 1325-1328, 1987.
