Publicação:
Genetic susceptibility to bleomycin: A twin study

Nenhuma Miniatura disponível

Data

1995-01-01

Autores

Orientador

Coorientador

Pós-graduação

Curso de graduação

Título da Revista

ISSN da Revista

Título de Volume

Editor

Tipo

Artigo

Direito de acesso

Acesso restrito

Resumo

The frequency of chromatid breaks was analysed in peripheral lymphocytes obtained from sixteen healthy monozygotic (MZ) and sixteen healthy dizygotic (DZ) pairs of twins. In addition, increases in the frequency of chromatid breaks, following in vitro treatment of whole blood with 0.03 unit/ml bleomycin (BLM), were analysed in the same twins. There was a highly significant intrapair difference in the variance of the frequency of chromatid breaks among MZ and DZ twins, before and after BLM treatment. The coefficient of heritability was 85,5% and it was concluded that genetic factors contributed significantly to the individual variation observed in BLM induced chromatid break rates.

Descrição

Palavras-chave

bleomycin, twins, variation (genetics), adolescent, adult, child, chromatid, chromosome breakage, dizygotic twins, female, genetic susceptibility, heredity, human, human experiment, in vitro study, male, monozygotic twins, normal human

Idioma

Inglês

Como citar

Revista de Ciencias Biomedicas, v. 16, p. 47-53.

URI

http://hdl.handle.net/11449/64586

Itens relacionados

Financiadores

Coleções

Botucatu - IBB - Instituto de Biociências

Unidades

Departamentos

Cursos de graduação

Programas de pós-graduação