Bioactive guanidine alkaloids from Pterogyne nitens
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Data
1995-12-01
Autores
Bolzani, Vanderlan da Silva [UNESP]
Gunatilaka, A. A. Leslie
Kingston, David G. I.
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Resumo
Bioactivity-guided fractionation of a methanolic CHCl 3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC 12=9.3-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B 1 cells (IC 50=8.5-13.0 μg/ml).
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Palavras-chave
guanidine derivative, nitensidine, pterogynidine, pterogynine, unclassified drug, antineoplastic activity, bioassay, carbon nuclear magnetic resonance, cytotoxicity, dna repair, drug activity, drug isolation, drug structure, proton nuclear magnetic resonance
Como citar
Journal of Natural Products, v. 58, n. 11, p. 1683-1688, 1995.