Publicação: Assessment of vitamin A status in chronic obstructive pulmonary disease patients and healthy smokers
Nenhuma Miniatura disponível
Data
1996-12-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
The relation between vitamin A status and the degree of lung airway obstruction was examined in a cross-sectional study of 36 male subjects aged 43-74 y who were assigned to five groups as follows: healthy nonsmokers (n = 7), healthy smokers (n = 7), mild chronic obstructive pulmonary disease (COPD-mild) patients (n = 9), COPD-moderate-severe patients (n = 7), and COPD-moderate-severe patients with exacerbation (+ex; n = 6). Smoking habits, pulmonary function tests, and energy-protein status were assessed; serum concentrations of retinyl esters, retinol, retinol binding protein, and transthyretin and relative dose responses were measured. In addition, 12 male smokers aged 45-61 y with mild COPD were randomly assigned to two groups for a longitudinal study: six subjects consumed vitamin A (1000 RE/d; COPD- vitamin A) and six subjects received placebo for 30 d. Lowered serum retinol concentrations were found in the COPD-moderate-severe and COPD-moderate- severe+ex groups. Measurements of vitamin A status in healthy smokers and in COPD-mild patients were not different from those in healthy nonsmokers. The improvement of pulmonary function test results after vitamin A supplementation [mean increase for 1-s forced expiratory volume (FEV1) = 22.9% in the COPD-vitamin A group] may support the assumption of a local (respiratory) vitamin A deficiency in patients with this disease.
Descrição
Palavras-chave
chronic obstructive pulmonary disease, pulmonary function tests, retinol circulating complex, Vitamin A status assessment, acute phase protein, albumin, alpha carotene, beta carotene, c reactive protein, ceruloplasmin, placebo, prealbumin, retinol binding protein, retinol ester, retinol palmitate, airway obstruction, chronic obstructive lung disease, cigarette smoking, clinical protocol, clinical trial, controlled clinical trial, controlled study, diet supplementation, disease severity, forced expiratory volume, lung function test, nutritional status, oral drug administration, randomized controlled trial, retinol deficiency, vitamin blood level, Analysis of Variance, Carotenoids, Cross-Sectional Studies, Diet, Intestinal Absorption, Liver, Longitudinal Studies, Lung, Lung Diseases, Obstructive, Middle Aged, Nutritional Status, Respiratory Function Tests, Smoking, Vitamin A, Vitamin A Deficiency
Idioma
Inglês
Como citar
American Journal of Clinical Nutrition, v. 64, n. 6, p. 928-934, 1996.
