Transplante pancreato-duodenal em ratos com microcirurgia. A téchnica e os resultados após 12 anos de experimentação
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Data
1996-12-01
Autores
Spadella, César Tadeu [UNESP]
Mercadante, Maria Cecília Salgado [UNESP]
Machado, José Lucio Martins [UNESP]
Schellini, Silvana Artioli [UNESP]
Macedo, Arthur Roquete de [UNESP]
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Resumo
In this study we present the technical details, adaptations and modifications of the original procedure of pancreaticoduodenal transplantation in rats described by Lee et al. in 1972. We also present the results and technical failures observed in a follow-up of 12 years. From March, 1982 to December, 1994, we performed in the Laboratory of Surgical Technique and Experimental Surgery of Faculty of Medicine, Botucatu - UNESP, Brazil, 665 duodenopancreatectomies in donor rats and 592 surgeries for revascularization of the pancreatic graft in recipient animals. The observed percentage of technical failures in donor rats was 11% due to bleeding and/or vascular complications, irregular flushing of the graft with saline and respiratory insufficiency. In recipients of grafts, we observed a percentage of technical failures of 22,5% due to porto-caval thrombosis, vascular bleeding, pancreatitis and graft ischemia. In both surgeries, the successful results are directly related to the technical performance of the surgeon and the cares in the postoperative period.
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Palavras-chave
Diabetes mellitus, Duodenum, Experimental, Pancreas transplantation, Surgery, Transplantation, animal, duodenum, experimental diabetes mellitus, female, follow up, human, Lewis rat, methodology, microsurgery, pancreas transplantation, pancreaticoduodenectomy, postoperative complication, rat, transplantation, treatment failure, Wistar rat, Animals, Diabetes Mellitus, Experimental, Female, Follow-Up Studies, Humans, Microsurgery, Pancreas Transplantation, Pancreaticoduodenectomy, Postoperative Complications, Rats, Rats, Inbred Lew, Rats, Wistar, Treatment Failure
Como citar
Arquivos de Gastroenterologia, v. 33, n. 3, p. 158-166, 1996.