Publicação: Plasma levels of transthyretin and retinol-binding protein in child-a cirrhotic patients in relation to protein-calorie status and plasma amino acids, zinc, vitamin a and plasma thyroid hormones
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Transthyretin and retinal-binding protein are sensitive markers of acute protein-calorie malnutrition both for early diagnosis and dietary evaluation. A preliminary study showed that retinal-binding protein is the most sensitive marker of protein-calorie malnutrition in cirrhotic patients, even those with the mild form of the disease (Child A). However, in addition to being affected by protein-calorie malnutrition, the levels of these short half-life-liver-produced proteins are also influenced by other factors of a nutritional (zinc, tryptophan, vitamin A, etc) and non-nutritional (sex, aging, hormones, renal and liver functions and inflammatory activity) nature. These interactions were investigated in 11 adult male patients (49.9 ± 9.2 years of age) with alcoholic cirrhosis (Child-Pugh grade A) and with normal renal function. Both transthyretin and retinol binding protein were reduced below normal levels in 55% of the patients, in close agreement with their plasma levels of retinal. In 67% of the patients (4/6), the reduced levels of transthyretin and retinal-binding protein were caused by altered liver function and in 50% (3/6) they were caused by protein-calorie malnutrition. Thus, the present data, taken as a whole, indicate that reduced transthyretin and retinal-binding protein levels in mild cirrhosis of the liver are mainly due to liver failure and/or vitamin A status rather than representing an isolated protein-calorie malnutrition indicator.
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Liver cirrhosis, Prealbumin, Protein binding, Protein-calorie malnutrition, Vitamin A, amino acid, prealbumin, retinol, retinol binding protein, thyroid hormone, zinc, adult, alcohol liver cirrhosis, blood, human, liver failure, male, metabolism, middle aged, protein calorie malnutrition, Adult, Amino Acids, Humans, Liver Cirrhosis, Alcoholic, Liver Failure, Male, Middle Aged, Protein-Energy Malnutrition, Retinol-Binding Proteins, Thyroid Hormones, Zinc
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Inglês
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Arquivos de Gastroenterologia, v. 34, n. 3, p. 139-147, 1997.
