Publicação: Effect of allopurinol in the course of adriamycin induced nephropathy
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The role of superoxide in adriamycin-induced nephropathy (single dose; i.v. 3 mg/kg) has been studied by blocking superoxide synthesis through the administration of allopurinol (500 mg/L in drinking water). In Experiment I (EI), allopurinol administration was started 3 days prior to nephropathy induction and continued until day 14. In Experiment II (EII) allopurinol administration was started 2 weeks after nephropathy induction and was maintained until the end of the experiment (26 weeks). Affected glomeruli frequency and tubulointerstitial lesion index (TILI) were determined at Weeks 2 and 4 (EI) and Week 26 (EII). In EI, and 24 h mean proteinuria in the nephrotic control group (NCG-I) differed from that of the treated nephrotic group (TNG-I) at Week 1 (TNG = 33.3 ± 6.39 mg/24 h; NCG = 59.8 ± 6.3 mg/24 h; p < 0.05) and 2 (NCG-I = 80.0 ± 17.5 mg/24h; TNG-I = 49.1 ± 8.4 mg/24 h; p < 0.05). No glomerular alterations were observed and TILI medians were not different in both nephrotic groups at week 2 (NCG-I = 1+: TNG = 1+) and 4 (NCG = 4+; TNG = 4+). In EII, NCG-II and TNG-II presented different 24 h proteinuria values only at Week 6, (136.91 ± 22.23 mg/24 h ad 72.66 ± 10.72 mg/24 h, respectively; p < 0.05). Between nephrotic groups, there was no statistical difference in the median of affected glomeruli (CNG-II = 56%; TNG-II = 48% and TILI (NCG-II = 8+; TNG-II = 9+). Thus, allopurinol was associated with a transient reduction in proteinuria and it did not alter the progression of the nephropathy.
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Adriamycin nephropathy, Allopurinol, Glomerulosclerosis, Proteinuria, Superoxide, allopurinol, doxorubicin, free radical, superoxide, animal model, controlled study, drug effect, drug induced disease, electron microscopy, glomerulosclerosis, intravenous drug administration, kidney biopsy, kidney disease, nephrotoxicity, priority journal, proteinuria, purine metabolism, Antineoplastic Agents, Biopsy, Disease Models, Animal, Disease Progression, Doxorubicin, Follow-Up Studies, Free Radical Scavengers, Glomerulosclerosis, Focal Segmental, Kidney Glomerulus, Kidney Tubules, Nephritis, Interstitial, Random Allocation, Rats, Wistar
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Inglês
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Renal Failure, v. 21, n. 2, p. 147-154, 1999.
