Publicação: Role of ticlopidine on adriamycin-induced nephropathy
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Data
1999-10-11
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Coorientador
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Artigo
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Resumo
The effect of ticlopidine on rats with adriamycin nephropathy was observed during 26 weeks. In the ticlopidine-treated nephrotic animals (TNG), proteinuria was less than in the untreated nephrotic animals (NG), but this difference was significant only at week 6 (TNG = 47.27 ± 16.52 versus NG = 100.08 ± 13.83 mg/24h, p < 0.01) and week 26 (TNG = 157.00 ± 28.73 versus NG = 217.00 ± 21.73 mg/24h, p< 0.01) after ADR injection. NG presented severe tubulointerstitial abnormalities with a tubulointerstitial lesion index of 3+. No difference in glomerular lesions was observed among the groups (NG median = 6%, TNG median = 4% and TCG median = 2%). The tubulointerstitial lesion index of TNG was less intense (median = 2+) but not different from those of the control groups (CG median = 1+; TCG median = 0+) nor NG (median = 3+). We concluded that the treatment with ticlopidine produced some partially beneficial effects but did not prevent the development of adriamycin-induced nephropathy.
Descrição
Palavras-chave
Adriamycin nephropathy, Antiplatelet agent, Progression of renal disease, Proteinuria, Ticlopidine, doxorubicin, ticlopidine, animal cell, animal model, animal tissue, controlled study, drug efficacy, drug mechanism, interstitial nephritis, intravenous drug administration, kidney disease, male, nonhuman, priority journal, proteinuria, rat, Animals, Antibiotics, Antineoplastic, Doxorubicin, Drug Evaluation, Preclinical, Kidney, Male, Nephrosis, Platelet Aggregation Inhibitors, Rats, Rats, Wistar, Statistics, Nonparametric, Time Factors
Idioma
Inglês
Como citar
Renal Failure, v. 21, n. 5, p. 469-475, 1999.
