Influence of antimicrobial subinhibitory concentrations on hemolytic activity and bacteriocin-like substances in oral: Fusobacterium nucleatum
Carregando...
Fonte externa
Fonte externa
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso restrito
Fonte externa
Fonte externa
Resumo
Fusobacterium nucleatum is considered for its role in colonization of initial and late microorganisms in dental plaque and for its coaggregation with other bacterial species. It is known that action of different antimicrobial substances may interfere with either virulence factors or with host-bacteria interaction. The goal of this study was to examine the influence of subinhibitory concentrations of chlorhexidine, triclosan , penicillin G and metronidazole on hemolytic activity and bacteriocin-like substance production of oral F. nucleatum. A high resistance to penicillin G was observed and 63% of the isolates were β-lactamase positive. All the tested isolates were susceptible to metronidazole. F. nucleatum isolates grown with or without antimicrobials were alpha-hemolytics. Bacteriocin-like substance production was increased in isolates grown with penicillin G. Impaired production of hemolytic or antagonic substances can suggest a role in the regulation of oral microbiota.
Descrição
Palavras-chave
Antimicrobial activity, Bacteriocin-like substances, Hemolytic activity, antiinfective agent, bacteriocin, chlorhexidine, hemolysin, metronidazole, penicillin G, triclosan, adult, biosynthesis, dose response, drug effect, Fusobacterium nucleatum, human, microbiology, mouth, periodontitis, Adult, Anti-Bacterial Agents, Bacteriocins, Chlorhexidine, Dose-Response Relationship, Drug, Hemolysin Proteins, Humans, Metronidazole, Mouth, Penicillin G, Periodontitis, Triclosan
Idioma
Inglês
Citação
New Microbiologica, v. 23, n. 2, p. 137-142, 2000.
