Chemistry and bioactivity of Raulinoa echinata Cowan, an endemic Brazilian rutaceae species
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The hexane extract of the stems of Raulinoa echinata afforded the sesquiterpenes germacrene D (6), 1β,6α-dihydroxy-4-(15)-eudesmene (4) and oplopanone (5); the triterpenes squalene, isomultiflorenol (7), isobauerenol (8) and friedelin (9); the protolimonoids melianone (2) and melianodiol (3); and the pyranocoumarin 3-(1′-1′-dimethylallyl)-lomatin (1), which has not been reported previously as a natural product; together with β-sitosterol. The hexane extract and some of these compounds were assayed in vitro against trypomastigote forms of Trypanosoma cruzi. Brine shrimp lethality and antimicrobial activities of the crude extract and pure compounds were also evaluated.
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Antimicrobial activity, Brine shrimp, Raulinoa echinata, Rutaceae, Trypanosoma cruzi, 1beta,6alpha dihydroxy 4(15) eudesmene, friedelin, germacrene D, isobauerenol, isomultiflorenol, melianodiol, melianone, oplopanone, plant extract, pyranocoumarin 3 (1',1' dimethylallyl)lomatin, sesquiterpene derivative, sitosterol, unclassified drug, animal experiment, animal model, antimicrobial activity, Artemia, bioassay, Brazil, carbon nuclear magnetic resonance, controlled study, drug activity, extract, nonhuman, plant, plant leaf, priority journal, proton nuclear magnetic resonance, spectrometry, Animals, Biological Assay, Coumarins, Ethnobotany, Humans, Plant Extracts, Plant Stems, Plants, Medicinal, Rosales, Sesquiterpenes, Triterpenes, Trypanocidal Agents, Animalia, Anostraca, Decapoda (Crustacea), Trypanosoma
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Inglês
Citação
Phytomedicine, v. 8, n. 2, p. 121-124, 2001.
