Hepatic gluconeogenesis in rats trained to eat a single meal daily. Role of eating periodicity and the amount of food ingested in the last meal
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
Rats trained to eat a single daily meal (MF rats), from 8:00-10:00 a.m., increased food intake from the 1 st to the 12 th (125%) day of feeding training. In this work we compared the influence of the higher food ingestion in the last meal and feeding training on hepatic gluconeogenesis. Thus, rats at the 1 st (MF 1st day-5g group) and 13 th day (MF 13th day-5g group) of training, refed with a fixed amount of food (5g) were employed. In addition, a third group of MF rats, refed on day 12 with 75% (12g) of the food ingested by MF rats on the 13 th day of the feeding training (MF 13th day-12g) was included. The experiments were performed at 22 h after meal (8:00 a.m.). Our results demonstrated that feeding training had a crucial role in determining gluconeogenesis from pyruvate (5 mM). Additionally, gluconeogenesis from L-glutamine (5 mM) was influenced by periodicity of eating and the amount of food ingested in the last meal. In contrast, gluconeogenesis from L-alanine (5 mM) was not influenced by both factors. In conclusion, our findings suggested that the hepatic gluconeogenesis was influenced by food ingestion and/or feeding training depending of the substrate investigated. These effects on gluconeogenesis may have implications for use in diabetic regimens.
Descrição
Palavras-chave
Eating schedules, Feeding training, Food intake, Gluconeogenesis, Implications in diabetes, L-glutamine and L-alanine and gluconeogenesis, Periodicity of eating, alanine, glutamine, pyruvic acid, animal experiment, animal model, controlled study, diabetic diet, feeding, food intake, gluconeogenesis, liver metabolism, male, nonhuman, priority journal, rat, Adaptation, Physiological, Animals, Blood Glucose, Eating, Glucose, Lactates, Liver, Liver Glycogen, Male, Periodicity, Rats, Rats, Wistar, Urea
Idioma
Inglês
Citação
Research Communications in Molecular Pathology and Pharmacology, v. 109, n. 5-6, p. 345-356, 2001.
