Publicação: Citotoxicidade de Styrax camporum Pohl em macrófagos peritoneais e a liberação de H2O2
Nenhuma Miniatura disponível
Data
2004-12-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
The immunological response includes wide contexts involving several cells, and the macrophage is crucial in the cellular immune response. Several stimuli to macrophage membrane may induce the liberation of H2O2, contributing to antibacterial and cytotoxicical actions. Nowadays, there is a tendency to study natural products to verify their capacity of acting in the immune system. This study evaluated the citotoxicity of the bulk extract and the hexanic and acetic fractions extracted from Styrax camporum Pohl (Styracaceae) and the production of H2O2, on murine peritonal macrophages cultures exposed to fractions extracted from this plant. The results showed that the fraction HX 2 mg/ml produced the liberation of H 2O2 in high concentrations and to 4 mg/ml was observed high citotoxicity. The fractions AC did not produce the liberation of H 2O2 and EB was produced in low levels. We conclude that this HX is a potent stimulator of macrophage.
Descrição
Palavras-chave
Cytotoxicity, Hydrogen peroxide, Macrophage, Styrax camporum, hydrogen peroxide, plant extract, Styrax camporum extract, unclassified drug, animal cell, controlled study, cytotoxicity, evaluation, extraction, immune response, immune system, medicinal plant, membrane transport, nonhuman, peritoneum macrophage, styrax camporum
Idioma
Português
Como citar
Revista de Ciencias Farmaceuticas, v. 25, n. 1, p. 31-35, 2004.
