In vitro release of propolis from gelatin microparticles prepared by spray-drying technique
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Data
2004-12-01
Autores
Bruschi, M. L. [UNESP]
Lopes, R. S. [UNESP]
Franco, S. L.
Gremião, Maria Palmira Daflon [UNESP]
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Resumo
The purpose of this study was to investigate the in vitro release of propolis from gelatin microparticles. Gelatin microparticles containing propolis extractive solution (PES) were prepared by spray-drying technique. Microparticles with a mean diameter of 2.50 μm and with regular morphology were obtained. The entrapment efficiency of propolis in the microparticles was over 39%. Spray-drying showed to be a feasible method for the preparation of gelatin microparticles containing propolis. Comparing to PES, the in vitro release of propolis from gelatin microparticles in aqueous medium was slower, considering markers 1 and 2. Thus, it was possible to transform a liquid propolis dosage form into a solid one, improving manipulation, packaging and storage and with modified release in aqueous medium, comparatively to the ethanolic extract of the drug.
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Palavras-chave
Gelatin, In vitro release, Microencapsulation, Microparticles, Propolis, Spray-drying, gelatin, nanoparticle, propolis, aqueous solution, drug release, feasibility study, in vitro study, morphology, spray drying, technique
Como citar
Revista de Ciencias Farmaceuticas, v. 25, n. 2, p. 79-84, 2004.