Publicação: Determination of flutamide in tablets by high-performance liquid chromatography
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Flutamide is a potent antiandrogen used for the treatment of prostatic cancer. A simple, sensitive and accurate high-performance liquid Chromatographic (HPLC) method is presented for quantitative determination of flutamide in tablets, using a reversed-phase technique and UV detection at 240 nm. The isocratic elution was used to quantify the analyte. The samples were chromatographed on Luna-C18 column and the mobile phase was 0.05 M phosphate buffer pH 4.0 - acetonitrile (50:50, v/v). The method was linear between 2.9 - 11.6 mg L -1. Over the tested concentration range the intra-day relative standard deviation for replicate analysis in tablets ranged from 0.44 to 0.78%. It was also found that the excipients in the commercial tablets did not interfere with the method.
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Analysis in tablets, Flutamide, High-performance liquid chromatography (HPLC), Pharmaceutical analysis, acetonitrile, flutamide, drug determination, high performance liquid chromatography, prostate cancer, reversed phase high performance liquid chromatography, tablet
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Inglês
Como citar
Acta Farmaceutica Bonaerense, v. 24, n. 2, p. 246-249, 2005.
