New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis
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Resumo
Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays. ©2005 Sociedade Brasileira de Química.
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Antifungal activity, Cassia spectabilis, Cytotoxic metabolites, Endophytic fungi, Phomopsis cassiae
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Journal of the Brazilian Chemical Society, v. 16, n. 6 B, p. 1463-1466, 2005.
