Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae
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2005-11-16
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In this study we investigated the effect of β-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 μg of glucan by i.p. route, were assayed. In vivo β-glucan administration primed spleen cells for a higher production of IL-12 and TNF-α when S. aureus was used as a stimulus. In addition, β-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for β-glucan were observed in this work. © 2005 Institute of Physiology, Academy of Sciences of the Czech Republic.
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β-glucan , Fungicidal activity , IL-12 , NK activity , TNF-α , beta glucan , interleukin 12 , tumor necrosis factor alpha , animal cell , animal experiment , cell activity , controlled study , cytokine production , drug effect , female , fungicidal activity , immunomodulation , mouse , natural killer cell , nonhuman , peritoneum cell , Saccharomyces cerevisiae , spleen cell , target cell , Animals , Antifungal Agents , beta-Glucans , Cytokines , Dose-Response Relationship, Drug , Female , Immunologic Factors , Killer Cells, Natural , Mice , Mice, Inbred C57BL , Paracoccidioides
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Physiological Research, v. 54, n. 5, p. 557-564, 2005.