Publicação: Força de compressão e umidade no perfil de dissolução da hidroclorotiazida
Nenhuma Miniatura disponível
Data
2006-01-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso aberto
Resumo
The aim of this work was to evaluate the influence of compression force and humidity in the dissolution profile of tablets formulation. As hidroclorotyiazide presents real problems of bioavailability, it was incorporate as standard drug in a formulation of tablets to study the mechanical resistance, time of disintegration and dissolution profile in function of humidity and compression force. The time of disintegration was not affected by the compression force, but it was influenced by humidity. The dissolution profile was altered by the compression force and for the humidity as well. Both factors can alter the bioavailability of drugs dispensed in the form of tablets.
Descrição
Idioma
Português
Como citar
Acta Farmaceutica Bonaerense, v. 25, n. 1, p. 104-107, 2006.
