Espécies reativas de oxigênio no controle neurovegetativo da pressão arterial
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Data
2006-01-01
Autores
Cardoso, Leonardo M.
Colombari, Débora S. A. [UNESP]
Menani, José Vanderlei [UNESP]
De Paula, Patrícia M. [UNESP]
Chianca Jr., Deoclécio A.
Colombari, Eduardo [UNESP]
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Resumo
The control of the blood pressure depends on the activity of select groups of neurons present in the central nervous system. Evidence has demonstrated that the redox state (a balance between oxidizing and reducing species) is involved in the control of neuronal activity, which suggests that the redox state can influence the neuronal transmission within the central nervous system acting on the neuronal modulation of biological functions. For instance, the glutamatergic transmission may be widely affected by reactive oxygen species, oxidizing agents that have been extensively investigated due to their involvement in physiological and pathological processes. In the present article, we discuss the main experimental finds that support the hypothesis that reactive oxygen species have important role in physiological (and pathological) modulation of the cardiovascular function through alterations in the sympathetic and parasympathetic system. Therefore, reactive oxygen species can actively participate in the development of cardiovascular diseases like hypertension when the balance in the redox state is disrupted.
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Palavras-chave
Cardiovascular Regulation, Glutamate, Hydrogen Peroxide, Reactive Oxygen Species, neurotransmitter, reactive oxygen metabolite, arterial pressure, autonomic nervous system, blood pressure regulation, cardiovascular system, central nervous system, cholinergic system, conference paper
Como citar
Medicina, v. 39, n. 1, p. 77-88, 2006.