Effects of olive oil and its minor constituents on serum lipids, oxidative stress, and energy metabolism in cardiac muscle
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Data
2006-02-01
Autores
Faine, Luciane A.
Rodrigues, Hosana G. [UNESP]
Galhardi, Cristiano M. [UNESP]
Ebaid, Geovana M. X.
Diniz, Yeda S.
Padovani, Carlos R. [UNESP]
Novelli, Ethel L. B.
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Resumo
Recent lines of evidence suggest that the beneficial effects of olive oil are not only related to its high content of oleic acid, but also to the antioxidant potential of its polyphenols. The aim of this work was determine the effects of olive oil and its components, oleic acid and the polyphenol dihydroxyphenylethanol (DPE), on serum lipids, oxidative stress, and energy metabolism on cardiac tissue. Twenty four male Wistar rats, 200 g, were divided into the following 4 groups (n = 6): control (C), OO group that received extra-virgin olive oil (7.5 mL/kg), OA group was treated with oleic acid (3.45 mL/kg), and the DPE group that received the polyphenol DPE (7.5 mg/kg). These components were administered by gavage over 30 days, twice a week. All animals were provided with food and water ad libitum The results show that olive oil was more effective than its isolated components in improving lipid profile, elevating high-density lipoprotein, and diminishing low-density lipoprotein cholesterol concentrations. Olive oil induced decreased antioxidant Mn-superoxide dismutase activity and diminished protein carbonyl concentration, indicating that olive oil may exert direct antioxidant effect on myocardium. DPE, considered as potential antioxidant, induced elevated aerobic metabolism, triacylglycerols, and lipid hydroperoxides concentrations in cardiac muscle, indicating that long-term intake of this polyphenol may induce its undesirable pro-oxidant activity on myocardium. © 2006 NRC Canada.
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Palavras-chave
Energy metabolism, Oleic acid, Olive oil, Oxidative stress, Polyphenols, carbonyl derivative, low density lipoprotein cholesterol, oleic acid, olive oil, polyphenol derivative, polyphenol dihydroxyphenylethanol, superoxide dismutase, unclassified drug, animal cell, animal experiment, antioxidant activity, controlled study, dose response, drug inhibition, drug mechanism, energy metabolism, heart muscle cell, in vivo study, male, nonhuman, oxidative stress, priority journal, Animals, Antioxidants, Dietary Fats, Unsaturated, Energy Metabolism, Flavonoids, Lipids, Male, Myocardium, Oleic Acid, Oxidative Stress, Phenols, Phenylethyl Alcohol, Plant Oils, Rats, Rats, Wistar
Como citar
Canadian Journal of Physiology and Pharmacology, v. 84, n. 2, p. 239-245, 2006.