Estudo multicêntrico Brasileiro - Adesivo contraceptivo transdérmico semanal: Preferência e satisfação das usuárias
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Data
2006-04-01
Autores
Ferriani, Rui A.
Andrade, Rosires P.
Neto, Luiz Ferraz
Nakagava, Hitomi M.
Dias, Rogerio [UNESP]
Finotti, Marta F.
Bacarat, Edmund C.
Freitas, Fernando M.
Tadini, Valdir
Neto, Antônio Aleixo
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Resumo
Background: To assess satisfaction with the weekly transdermal contraceptive patch, compared to the previous contraceptive method. Adhesion, cycle control, safety and efficacy were secondary outcomes. Methods: A multicenter, open label, descriptive study. Subjects received the weekly transdermal contraceptive patch for 6 cycles. At the baseline and after the 1 st, 3 rd and 6 th cycles, satisfaction with the method was assessed. The contraceptive efficacy was assessed by the Pearl Index and by life table analysis. Results: An ITT analysis was performed with 494 subjects. At the endpoint, 95.3% of women were satisfied with the patch compared to the previous method; 59.5%, 58.0% and 63.2% of women reported improvement in the physical and emotional well-being, and pre-menstrual symptoms, respectively. Pre-menstrual symptoms frequency decreased from 85.0% (CI 95%: 80.8-87.4%) to 55.0% (CI 95%: 49.9-66.0%). There was a significant increase in hemoglobin levels, and also a significant decrease in total serum cholesterol and tryglicerides.. There were no significant adverse events. The adjusted Pearl Index was 1.1 pregnancies per 100 women-years. Conclusions: The weekly contraceptive transdermal patch is a safe and effective method, and there was a high rate of satisfaction with its use among brazilian women. The patch was associated to a good cycle control, with easiness of use, improvement in the physical and emotional well-being and improvement in the premenstrual symptoms and lipid profile. © Copyright Moreira Jr. Editora. Todos os direitos reservados.
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cholesterol, contraceptive agent, hemoglobin, triacylglycerol, adult, cholesterol blood level, contraception, controlled study, emotion, female, human, human experiment, menstrual cycle, pregnancy, premenstrual syndrome, safety, satisfaction, transdermal patch, triacylglycerol blood level
Como citar
Revista Brasileira de Medicina, v. 63, n. 4, p. 144-151, 2006.