Publicação: Articaine and mepivacaine efficacy in postoperative analgesia for lower third molar removal: a double-blind, randomized, crossover study
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Objective: Comparison of the clinical efficacy of 4% articaine in relation to 2% mepivacaine, both with 1:100,000 epinephrine, in the prevention of postoperative pain after lower third molar removal. Study design: Twenty patients underwent removal of bilateral lower third molars under local anesthesia (articaine or mepivacaine) in 2 separate appointments, in a double-blind, randomized, and crossed manner. Objective and subjective parameters were recorded for paired comparison of postoperative courses. Results: Duration of analgesia provided by articaine and mepivacaine was 198.00 ± 25.86, and 125.40 ± 13.96 min, respectively (P = .02), whereas the duration of anesthesia was 273.80 ± 15.94 and 216.85 ± 20.15 min, respectively (P = .06). Both solutions exerted no important effects upon arterial pressure, heart rate, or oxygen saturation (P > .05). Conclusions: Articaine provides a longer period of analgesic effect and a tendency for a longer period of anesthesia as compared to mepivacaine. The presence of a vasoconstrictor agent in local anesthetic solutions does not seem to influence hemodynamic parameters during lower third molar removal in healthy subjects. © 2006 Mosby, Inc. All rights reserved.
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articaine, local anesthetic agent, mepivacaine, nonsteroid antiinflammatory agent, piroxicam, adolescent, adult, clinical trial, controlled clinical trial, controlled study, crossover procedure, dental anesthesia, double blind procedure, female, human, local anesthesia, male, methodology, molar tooth, postoperative pain, randomized controlled trial, tooth disease, tooth extraction, Adolescent, Adult, Anesthesia, Dental, Anesthesia, Local, Anesthetics, Local, Anti-Inflammatory Agents, Non-Steroidal, Carticaine, Cross-Over Studies, Double-Blind Method, Female, Humans, Male, Mepivacaine, Molar, Third, Pain, Postoperative, Piroxicam, Tooth Extraction, Tooth, Impacted
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Inglês
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Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, v. 102, n. 2, p. 169-174, 2006.
