Variabilidade clínica na determinação da dose tóxica oral em intoxicação experimental por fluoroacetato de sódio em gatos
Carregando...
Data
2006-12-01
Autores
de Collicchiozuanaze, Rita Cássia [UNESP]
Sakate, Michiko [UNESP]
Crocci, Adalberto José [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
The sodium monofluoroacetate (FAC) or compound 1080 is a potent rodenticide used for a rodents and vertebrate pest control. It was prohibited in many countries because of its high toxicity, but in Brazil exist evidences of ilegal use causing the intoxication in children and domestic animals. The fluoroacetate metabolite, fluorocitric acid, blocks body energy production by inhibit the Krebs cycle, resulting in neurological and cardiacs signs. In the present study, four group of oral toxic dosis of the FAC were compared in cats. The best oral toxic dose for clinical signs presentation, without cause acute lethality, was 0,45mg/kg. The clinical variability was dosis dependent and its intensity, in crescent order, was: light signs (dose 1: 0,3mg/kg), light to moderate (dose 2: 0,4mg/kg), moderate to severe (dose 3: 0,45mg/ kg) and severe (dose 4: 0,5mg/kg). There was individual clinical variability between animals that received the same oral toxic dose.
Descrição
Palavras-chave
Clinical variability, Intoxication, Oral toxic dosis, Rodenticide, Sodium monofluoroacetate, Animalia, Rodentia, Vertebrata
Como citar
Brazilian Journal of Veterinary Research and Animal Science, v. 43, n. 1, p. 117-124, 2006.