Effects of nitric oxide and arginine vasopressin on water intake induced by central angiotensin II. Part 1
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Data
2007-07-01
Autores
Saad, Wilson Abrão [UNESP]
Guarda, Ismael Francisco Motta Sigueira
De Arruga Camargo, Luis Antonio [UNESP]
Brizola dos Santos, Talmir Augusto Faria
Saad, William Abrão
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Resumo
We determined the effects of AT 1 and AT 2 (selective no peptides antagonists angiotensin receptors), arginine vasopressin V 1 receptor antagonist as well as L-arginine, a nitric oxide donor and N W-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, injected into supraoptic nucleus (SON) on water and sodium intake induced by the injection of angiotensin II (ANGII). Male Holtzman rats weighing 200-250 g with canulae implanted into the SON were used. The drugs were injected in 0.5 μL over 30-60 sec. The water intake after injection of saline SAL+SAL 0.15 M NaCl was 0.40±0.1 mL 2 h -1; SAL+ANGII increase water intake. Losartan decreased the water intake induced by ANGII. PD123319 injected prior to produce no change in water intake induced by ANGII. AVPA prior to ANGII reduced the water intake with a less intensity than losartan. L-arginine prior to ANGII decreases the water intake at a same intensity than losartan. L-NAME prior to ANGII potentiated the dipsogenic effect of ANGII. Losartan injected simultaneously with L-arginine prior to ANGII blocked the dipsogenic effect of ANGII. These results confirm the importance of SON in the control of water intake and strongly suggest that AT 1, V 1 receptors interact with nitrergic pathways within the SON influencing the dipsogenic effect of ANGII.
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Angiotensin AT 1,2 receptors, CNS, NO, V 1 receptors, Water intake, 1 (4 dimethylamino 3 methylbenzyl) 5 diphenylacetyl 4,5,6,7 tetrahydro 1h imidazo[4,5 c]pyridine 6 carboxylic acid, angiotensin I, angiotensin II, angiotensin receptor, arginine, argipressin, argipressin receptor, argipressin[1 (3,3 cyclopentamethylene 3 mercaptopropionic acid) 2 (o methyltyrosine)], losartan, n(g) nitroarginine methyl ester, nitric oxide, nitric oxide donor, nitric oxide synthase inhibitor, sodium chloride, animal experiment, animal tissue, cannula, controlled study, fluid intake, nonhuman, rat, sodium intake, Sprague Dawley rat, supraoptic nucleus, thirst
Como citar
Journal of Medical Sciences, v. 7, n. 5, p. 845-849, 2007.