Determinação de fármacos diuréticos em associação por cromatografia em camada delgada e espectrofotometria

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Data

2008-03-11

Autores

Valladão, Dênia Mendes de Sousa
Ionashiro, Massao [UNESP]
Netto, José Zuanon

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Resumo

A rapid, sensitive and reliable thin-layer chromatography/spectrophotometry screening procedure was developed for quantitative determination of diuretics associated in pharmaceutical dosage forms. The chromatographic method employed microcrystalline cellulose and butanol : acetic acid : water (4:1:1) or amilic alcohol : ammonium hydroxide 25% (9:1) as mobile phases and detection by U.V. light. The drugs were extracted using a simple procedure and were quantified by U.V. spectrophotometry. Results varied from 97.5 to 102.5% and are similar to those obtained by conventional methods. This method of quantification of diuretics is promising for quality control of drugs.

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Palavras-chave

Diuretics, Quality control, Thin layer chromatography

Como citar

Quimica Nova, v. 31, n. 1, p. 44-46, 2008.