Publicação: Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production
Carregando...
Data
2009-10-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso aberto
Resumo
The effects of isolated compounds from Brazilian lichens and their derivatives on H 2O 2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H 2O 2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H 2O 2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.
Descrição
Palavras-chave
Hydrogen peroxide, Lichens, Macrophages, Nitric oxide, Phenolic compounds, 8' o n propyl norstitic acid, 9' o ethyl norstitic acid, 9' o ethyl protocetraric acid, 9' o iso propyl protocetraric acid, 9' o methyl protocetraric acid, 9' o n butyl protocetraric acid, 9' o n hexyl protocetraric acid, 9' o n pentyl protocetraric acid, 9' o n propyl protocetraric acid, 9' o sec butyl protocetraric acid, 9' o terc butyl protocetraric acid, comprotocetraric acid, hydrogen peroxide, immunostimulating agent, lichexanthone, methyl protocetrate, nitric oxide, nitroblue tetrazolium, norstitic acid, phenol derivative, physodic acid, protocetraric acid, unclassified drug, animal cell, cell stimulation, cell viability, cytotoxicity, drug determination, drug structure, drug synthesis, immune response, immunomodulation, lichen, macrophage, mouse, nonhuman, peritoneum, structure activity relation, supernatant, Swiss Webster mouse
Idioma
Inglês
Como citar
Brazilian Journal of Pharmacognosy, v. 19, n. 4, p. 847-852, 2009.
