Publicação: Brazilian experience with the medium-term multi-organ bioassay: Scientific and regulatory developments
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In 1996 the Brazilian Institute for the Environment (IBAMA) officially adopted a variation of the multiorgan initiation-promotion DMBDD bioassay as a valid source of evidence of the carcinogenic potential of pesticides. The protocol adopted by IBAMA was a modification of the one originally proposed by researchers led by Nobuyuki Ito, from the Nagoya City University Medical School. Among the modifications established in the Brazilian protocol were the use of both sexes of the outbreed Wistar strain of rats and two positive control test chemicals. The adoption of the modified DMBDD protocol was instrumental during the last decade for qualifying technical people and to spread knowledge on chemical carcinogenesis in Brazil.
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Cell proliferation, Estrogen, Immunosuppression, Mutagen/carcinogen screening, Two-year bioassay, carcinogen, animal, antibody specificity, bioassay, Brazil, carcinogen testing, chemically induced disorder, conference paper, drug effect, experimental neoplasm, female, Fischer 344 rat, government regulation, male, pathology, rat, standard, Animals, Biological Assay, Carcinogenicity Tests, Carcinogens, Female, Government Regulation, Male, Neoplasms, Experimental, Organ Specificity, Rats, Rats, Inbred F344
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Inglês
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Asian Pacific Journal of Cancer Prevention, v. 11, n. 1, p. 7-8, 2010.
