Publicação: SFlt-1 and IP-10 in women with early-onset preeclampsia
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Intense inflammatory response and an anti-angiogenic state have been implicated in the pathogenesis of preeclampsia. Here, we investigated this hypothesis evaluating the serum concentrations of CXCL10/IP-10, sFlt-1, and PlGF in women with early-onset preeclampsia. CXCL10/IP-10 was measured by Cytometric Bead Array. sFlt-1 and PlGF were measured by automated electrochemiluminescence immunoassay. The median serum concentration of CXCL10/IP-10 was 109.5 pg/mL in preeclamptic women, as compared with 52.28 pg/mL in the controls (P = 0.0028). The mean serum level of sFlt-1 was 13,636 pg/mL in preeclamptic women, as compared with 2020 pg/mL in the controls (P < 0.0001). PlGF levels were significantly lower in women with preeclampsia. © 2011 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
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Angiogenic factors, Inflammation, IP-10, PlGF, Preeclampsia, sFlt-1, gamma interferon inducible protein 10, placental growth factor, vasculotropin receptor 1, adult, chemoluminescence, clinical article, controlled study, cytometry, female, human, hypothesis, immunoassay, inflammation, pathogenesis, preeclampsia, protein blood level
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Pregnancy Hypertension, v. 1, n. 2, p. 129-131, 2011.
