Advances in sickle cell disease treatment: From drug discovery until the patient monitoring
Data de publicação2011-04-01
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Sickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world. Despite the immense progress in molecular knowledge about SCD in last years few therapeutical sources are currently available. Nowadays the treatment is performed mainly with drugs such as hydroxyurea or other fetal hemoglobin inducers and chelating agents. This review summarizes current knowledge about the treatment and the advancements in drug design in order to discover more effective and safe drugs. Patient monitoring methods in SCD are also discussed. © 2011 Bentham Science Publishers Ltd.
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Santos, Jean Leandro dos ; Chin, Chung Man (Current Medicinal Chemistry, 2011) [Resenha]Sickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world. SCD is a genetic disease characterized by punctual mutation that basis on the exchange of glutamic acid to valine in a beta chain ...
HPLC determination of hemoglobins to establish reference values with the aid of statistics and informatics Ondei, L. S. ; Zamaro, P. J A ; Mangonaro, P. H. ; Valêncio, C. R. ; Bonini-Domingos, C. R. (Genetics and Molecular Research, 2007) [Artigo]The purpose of the present study was to establish reference values for hemoglobins (Hb) using HPLC, in samples containing normal Hb (AA), sickle cell trait without alpha-thalassemia (AS), sickle cell trait with alpha-thalassemia ...
Naoum, P. C.; Teixeira, U. A.; Machado, P. E. de Abreu; Michelin, O. C. (Brazilian Journal of Medical and Biological Research, 1978) [Artigo]Human oxyhaemoglobin A and A2 from normal individuals and oxyhaemoglobin S from patients with sickle cell anaemia and sickle cell trait were studied using Isopropanol/buffer method at 37°C and 40°C. Hb S was less stable ...