Intravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two cases
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso aberto
Resumo
We report here two postmortem cases of dogs with intravascular lymphomatosis affecting the central nervous system. Intravascular lymphomatosis is represented by an exclusively intravascular proliferation of neoplastic lymphoid cells. To characterize the origin of the neoplastic cells, we have proceeded with immunohistochemical analysis to identify B and T lymphocytes and endothelial cells. The results showed predominance of cells from the T cell lineage, and no evidence of B cell origin was found. Few cells from one dog also exhibited cytoplasmatic staining for vimentin and Von Willebrand factor. Although in one case some immunophenotype diversity was observed, the massive presence of CD3 positive cells confirmed these neoplasms as intravascular lymphomatosis of T cell origin.
Descrição
Palavras-chave
Cell marker, Immunohistochemistry, Lymphoproliferative disorder, Neoplasia, Neuropathology, T cell, Canis familiaris
Idioma
Inglês
Citação
Brazilian Journal of Veterinary Pathology, v. 4, n. 1, p. 47-51, 2011.
