Publicação: Antiviral activity of plants occurring in the state of minas gerais (Brazil): Part III
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Data
2011-08-12
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Coorientador
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Artigo
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Resumo
A total of 24 extracts from 14 plant species collected at the state of Minas Gerais, Brazil, and belonging to five botanical families (Annonaceae, Apocynaceae, Ochnaceae, Polygonaceae and Vitaceae) was screened for cytotoxicity in cultured Vero cells and for antiviral activity against human herpes virus type 1 (HSV-1), vaccinia virus (VACV) and murine encephalomyocarditis virus (EMCV). The highest cytotoxicity (CC 50 < 10 μg/mL) was observed for the ethanol extracts from Annona coriacea fruits and seeds. Extracts from Hancornia speciosa, Ouratea castaneafolia and O. semisrrata were the only ones that have shown activity against all the three viruses assayed. Extracts from Polygonum spectabile, Hancornia speciosa, Himatanthus phagedaenica, Ouratea spectabilis and O. semiserrata were the most active against HSV-1 (EC 50 < 50 mg/mL), with favorable SI values (8.0 to 10.0). Hancornia speciosa and Anaxagorea dolichocarpa were the most active against EMCV (EC 50 50 - 100 μg/mL), with reasonable SI values (5.2 to 6.1), while moderate to low activity (EC 50 > 100 μg/mL) was observed for Ouratea spectabilis and O. semiserrata. A total of 7 plant species, Ouratea semiserrata, O. spectabilis, O. castanaeafolia, Rollinia laurifolia, Cissus erosa, Polygonum spectabile, and Hancornia speciosa, were active against VACV, disclosing EC50 < 50 μg/mL and SI values ranging from 6.6 to 67.3. In total, 10 out of the 14 species were selected from a literature survey on plants used to treat viral diseases in Brazil; these species were responsible for 70% of the positive results.
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Palavras-chave
Antiviral activity, Bioprospection, Emcv, Hsv-1, Vacv, Anaxagorea dolichocarpa extract, Annona coriacea extract, antivirus agent, Aspidosperma cylindrocarpon extract, Aspidosperma parvifolium extract, Aspidosperma tomentosum extract, Cissus erosa extract, Hancornia speciosa extract, Himatanthus phagedaenicus extract, Ouratea castaneifolia extract, Ouratea semiserrata extract, Ouratea spectabilis extract, plant extract, Polygonum spectabile extract, Rollinia laurifolia extract, Tabernaemontana laeta extract, unclassified drug, Anaxagorea dolichocarpa, angiosperm, animal cell, Annona coriacea, Annonaceae, antiviral activity, Apocynaceae, Aspidosperma cylindrocarpon, Aspidosperma parvifolium, Aspidosperma tomentosum, Brazil, Cissus erosa, controlled study, cytotoxicity test, drug cytotoxicity, drug screening, fruit, geographical variation (species), Hancornia speciosa, Herpes simplex virus 1, high performance liquid chromatography, Himatanthus phagedaenicus, in vitro study, mouse, Murine encephalomyelitis virus, nonhuman, Ochnaceae, Ouratea castaneifolia, Ouratea semiserrata, Ouratea spectabilis, plant leaf, plant seed, Polygonum spectabile, Rollinia laurifolia, Tabernaemontana laeta, Vaccinia virus, Vero cell, virus titration, Vitaceae
Idioma
Inglês
Como citar
Journal of Chemical and Pharmaceutical Research, v. 3, n. 4, p. 223-236, 2011.
