11-Oxoaerothionin isolated from the marine sponge Aplysina fistularis shows anti-inflammatory activity in LPS-stimulated macrophages
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Data
2012-12-01
Autores
Medeiros, Alexandra Ivo de [UNESP]
Gandolfi, Renata C.
Secatto, Adriana
Falcucci, Romulo M.
Faccioli, Lucia H.
Hajdu, Eduardo
Peixinho, Solange
Berlinck, Roberto G. S.
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Título de Volume
Editor
Informa Healthcare
Resumo
Marine sponges of the order Verongida are a rich source of biologically active bromotyrosine-derived secondary metabolites. However, none of these compounds are known to display anti-inflammatory activity. In the present investigation, we report the anti-inflammatory effects of 11-oxoaerothionin isolated from the Verongida sponge Aplysina fistularis. When RAW264.7 cells and primary macrophages were preincubated with 11-oxoaerothionin and stimulated with LPS (lipopolysaccharide), a concentration-dependent inhibition of iNOS (inducible nitric oxide synthase) protein and NO2- (Nitrite) production were observed. The same effect was observed when proinflammatory cytokines and PGE(2) (Prostaglandin E2) production was evaluated. In summary, we demonstrated that in the presence of LPS, 11-oxoaerothionin suppresses NO2 and iNOS expression as well as inflammatory cytokines and PGE(2).
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Prostaglandin E2, macrophages, inflammatory cytokines, nitric oxide, NF-kappa B and lipopolysaccharide
Como citar
Immunopharmacology and Immunotoxicology. London: Informa Healthcare, v. 34, n. 6, p. 919-924, 2012.