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PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution

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Elsevier B.V.

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Artigo

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Resumo

Praziquantel has been shown to be highly effective against all known species of Schistosoma infecting humans. Spherical nanoparticulate drug carriers made of poly(D,L-lactide-co-glycolide) acid with controlled size were designed. Praziquantel, a hydrophobic molecule, was entrapped into the nanoparticles with theoretical loading varying from 10 to 30% (w/w). This investigates the effects of some process variables on the size distribution of nanoparticles prepared by emulsion-solvent evaporation method. The results show that sonication time, PLGA and drug amounts, PVA concentration, ratio between aqueous and organic phases, and the method of solvent evaporation have a significant influence on size distribution of the nanoparticles. (C) 2004 Elsevier B.V. All rights reserved.

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nanoparticles, controlled release, PLGA, praziquantel, emulsification evaporation method

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Inglês

Citação

International Journal of Pharmaceutics. Amsterdam: Elsevier B.V., v. 290, n. 1-2, p. 137-144, 2005.

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Unidade
Faculdade de Ciências Farmacêuticas
FCF
Campus: Araraquara


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