Immunomodulatory/anti-inflammatory effects of Baccharis dracunculifolia leaves
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A possible immunomodulatory/anti-inflammatory effect of Baccharis dracunculifolia (Bd) and its major compound - caffeic acid (Ca) - on cytokines production (IL-1b, IL-6 and IL-10) by murine macrophages was investigated. Cells were incubated with Bd and Ca, and the inhibitory concentrations were tested before or after macrophages challenge with LPS. Bd and Ca stimulated IL-1b and inhibited IL-6 and IL-10 production. In LPS-challenge protocols, Bd prevented LPS action either before or after LPS challenge, whereas Ca prevented LPS effects only after LPS addition. Bd modulatory action on cytokines production may be at least in part mediated by Ca, since it has been shown to inhibit the transcription factor NF-kB. Further studies are still needed to evaluate Bd efficacy in inflammatory diseases, in order to explore its antiinflammatory activity in vivo. © 2013 Taylor & Francis.
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Baccharis dracunculifolia, Caffeic acid, Cytokines, Immunomodulation, 2,2 dimethyl 6 carboxyethenyl 2h 1 benzopyran acid, antiinflammatory agent, artepilin C, Baccharis dracunculifolia extract, caffeic acid, dexamethasone, ferulic acid, immunoglobulin enhancer binding protein, immunomodulating agent, interleukin 10, interleukin 1beta, interleukin 6, isosakuranetin, lipopolysaccharide, plant extract, unclassified drug, veratraldehyde, animal cell, antiinflammatory activity, controlled study, cytokine production, drug mechanism, immunomodulation, in vitro study, mouse, nonhuman, peritoneum macrophage, plant leaf, provocation test
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Natural Product Research, v. 27, n. 18, p. 1646-1650, 2013.
