Is there a role for eIF5A in translation?
Nenhuma Miniatura disponível
Data
2007-08-01
Autores
Zanelli, Cleslei Fernando [UNESP]
Valentini, Sandro Roberto [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Springer
Resumo
The putative translation factor eIF5A is essential for cell viability and is highly conserved from archaebacteria to mammals. This factor is the only cellular protein that undergoes an essential posttranslational modification dependent on the polyamine spermidine, called hypusination. This review focuses on the functional characterization of eIF5A. Although this protein was originally identified as a translation initiation factor, subsequent studies did not support a role for eIF5A in general translation initiation. eIF5A has also been implicated in nuclear export of HIV-1 Rev and mRNA decay, but these findings are controversial in the literature and may reflect secondary effects of eIF-5A function. Next, the involvement of eIF5A and hypusination in the control of the cell cycle and proliferation in various organisms is reviewed. Finally, recent evidence in favor of reconsidering the role of eIF5A as a translation factor is discussed. Future studies may reveal the specific mechanism by which eIF5A affects protein synthesis.
Descrição
Palavras-chave
eIF5A, hypusine, ribosome, translation, protein synthesis
Como citar
Amino Acids. New York: Springer, v. 33, n. 2, p. 351-358, 2007.