Alginate-chitosan systems: In vitro controlled release of triamcinolone and in vivo gastrointestinal transit

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Data

2010-06-11

Autores

Lucinda-Silva, Ruth Meri
Salgado, Hérida Regina Nunes [UNESP]
Evangelista, Raul Cesar [UNESP]

Título da Revista

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Título de Volume

Editor

Elsevier B.V.

Resumo

The aim of this study was to develop multiparticulate therapeutic systems of alginate (AL) and chitosan (CS) containing triamcinolone (TC) to colonic drug delivery. Multiparticulate systems of AL-CS, prepared by a complex coacervation/ionotropic gelation method, were characterized for morphological and size aspects, swelling degree, encapsulation content and efficiency, in vitro release profile in different environments simulating the gastrointestinal tract (GIT) and in vivo gastrointestinal transit. The systems showed suitable morphological characteristics with particle diameters of approximately 1.6 mm. In simulated gastric environment, at pH 1.2, the capsules presented low degree of swelling and in vitro release of drug. A higher swelling degree was observed in simulated enteric environment, pH 7.5, followed by erosion. Practically all the drug was released after 6 h of in vitro assay. The in vivo analysis of gastrointestinal transit, carried out in rats, showed that the systems passed practically intact through the stomach and did not show the same profile of swelling observed in the in vitro tests. It was possible to verify the presence of capsules in the colonic region of GIT. The results indicate that AL-CS multiparticulate systems can be used as an adjuvant for the preparation of therapeutic systems to colonic delivery of drugs. (C) 2010 Elsevier Ltd. All rights reserved.

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Palavras-chave

Alginate, Chitosan, Colonic drug delivery, Triamcinolone, Gastrointestinal transit

Como citar

Carbohydrate Polymers. Oxford: Elsevier B.V., v. 81, n. 2, p. 260-268, 2010.