Estabelecimento de condições para ensaio de dissolução de cápsulas de cinarizina empregando planejamento fatorial
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Data
2011-01-01
Autores
Gehring, Patrícia Alves Franco
Santos, Olímpia Maria Martins
Pereira, Gislaine Ribeiro
Araújo, Magali Benjamim de
Bonfilio, Rudy [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
This work describes the establishment of dissolution test conditions for 75 mg cinnarizine capsules using a multivariate approach. A 2³ full factorial design was carried out to achieve the best conditions and HCl 0.1 mol L-1 as dissolution medium, basket as apparatus at 100 rpm and collect time at 30 min were considered adequate. The quantification was carried out by spectrophotometry at 251 nm. Both dissolution procedure and analytical method were validated and all parameters were within the acceptable limits. Since there is no official monograph for this pharmaceutical product, this dissolution test could be applied for quality control routine.
Descrição
Palavras-chave
dissolution test, cinnarizine, 2³ full factorial design
Como citar
Química Nova. Sociedade Brasileira de Química, v. 34, n. 3, p. 455-461, 2011.