Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
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Data
2009-01-01
Autores
Pavan, Fernando Rogério [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
Coelho, Roberta Gomes
Coutinho, Isabel Duarte
Honda, Neli Kika
Cardoso, Claudia Andréa Lima
Vilegas, Wagner [UNESP]
Leite, Sergio Roberto de Andrade [UNESP]
Sato, Daisy Nakamura
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.
Descrição
Palavras-chave
Campomanesia adamantium, anti-Mycobacterium tuberculosis, flavonoids
Como citar
Química Nova. Sociedade Brasileira de Química, v. 32, n. 5, p. 1222-1226, 2009.