Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
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Sociedade Brasileira de Química
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Acesso aberto
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Resumo
The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.
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Campomanesia adamantium, anti-Mycobacterium tuberculosis, flavonoids
Idioma
Inglês
Citação
Química Nova. Sociedade Brasileira de Química, v. 32, n. 5, p. 1222-1226, 2009.
