Efeitos do citrato de sufentanil, administrado em infusão contínua, na concentração alveolar mínima (CAM) de isofluorano em felinos
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Data
2010-04-26
Autores
Dessen, Marina Regatieri [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
Opioides reduzem a CAM de agentes inalatórios em diversas espécies. O objetivo do presente estudo foi avaliar o efeito de três doses de sufentanil ,administradas em infusão contínua, na CAMiso em felinos. Oito gatos adultos e castrados (4.0±0.5 kg-1) foram anestesiados com isofluorano em três ocasiões distintas com um intervalo mínimo de sete dias mantidos em ventilação mecânica. A temperatura esofágica foi mantida na faixa de 38.5 a 39.0°C. Uma das três doses de sufentanil (0.01; 0.025 e 0.05 μg kg-1 minuto-1) foi selecionada aleatoriamente e infundida em cada experimento. A CAMiso basal individual, a CAMiso durante a infusões e a CAMiso após uma hora do término da infusão foram determinadas em todos os experimentos. As infusões eram feitas por 60 minutos antes da determinação da CAMISO em cada dose de sufentanil. As determinações da CAMISO foram realizadas de modo duplicado usando estímulo elétrico (50 V, frequência 50, 10 ms) aplicados nos antebraço. FC, PAS, PAM, PAD, EtCO2 e análise hemogasométrica eram registrados antes de cada determinação da CAMiso. Dados (média ± SD) foram analisados por ANOVA seguido do teste de Tukey (p<0.05%). Os valores de CAMbasal não diferiram estatisticamente (1.64±0.13; 1.61±0.24 e 1.62±0.31%). As infusões de sufentanil (0.01; 0.025 e 0.05 μg μg kg-1 minuto-1) reduziram significativamente a CAMISO 21.4±10.8; 18.5±10.5 e 18.0±13.7%, respectivamente. Não houve diferença significativa entre os valores de CAMISO durante as infusões.Os valores de CAMISO controle (1.56±0.26; 1.50±0.22 e 1.53±0.26%) foram inferiores da CAMISO basal indicando um possível efeito residual do opioide após a descontinuação da infusão. Os valores de FC e das pressões arteriais aumentaram durante as infusões de sufentanil 0.025 e 0.05 μg kg-1 minuto-1. As três doses de sufentanil infundidas resultaram em graus semelhantes...
Opioids reduce the MAC of Inhalants agents in many species. The aim of this study was to evaluate the effects of three sufentanil constant rate infusions (CRIs) on the MACISO in cats. Eight adult spayed cats (4.0±0.5 kg-1) were anesthetized with isoflurane under mechanical ventilation on three occasions with a minimum 7-day interval between. Esophageal temperature was maintained within a narrow range (38.5 to 39.0°C). One of three sufentanil CRIs (0.01; 0.025 and 0.05 μg kg-1 minute-1) was randomly selected to be administered on each day of MACISO determinations. On all study days, the individual basal MACISO (MACbasal), the MACISO during one of the infusion rates, and the control one hour post-infusion MAC (MACcontrol) were determined. CRI was continued for 60 minutes before MACISO was determined for each sufentanil dose. The MACISO determinations were performed in duplicate using an electrical stimulus (50V, 50 cycles second-1, 10 ms) applied to the antebrachium. HR, SAP, MAP, DAP, ETCO2, and arterial blood gases were recorded before and after each MACISO determination. Data (mean±SD) were compared by ANOVA followed by Tukey’s test (p<0.05%).MACbasal values were not significantly different (1.64±0.13; 1.61±0.24 and 1.62±0.31%). Sufentanil CRIs (0.01; 0.025 and 0.05 μg kg-1 minute-1) significantly reduced MACISO by 21.4±10.8; 18.5±10.5 and 18.0±13.7%, respectively. There were no significant differences between the MACISO values determined during the CRIs. The MACcontroll values (1.56±0.26; 1.50±0.22 and 1.53±0.26%) were different from MACbasal indicating the possibility of a residual opioid effect after the discontinuation of infusions. HR and blood pressure values increased during infusion of the higher sufentanil CRIs (0.025 and 0.05 μg kg-1 minute-1). The three CRI doses of sufentanil resulted in similar degrees of MACISO reduction in cats, indicating that... (Complete abstract click electronic access below)
Opioids reduce the MAC of Inhalants agents in many species. The aim of this study was to evaluate the effects of three sufentanil constant rate infusions (CRIs) on the MACISO in cats. Eight adult spayed cats (4.0±0.5 kg-1) were anesthetized with isoflurane under mechanical ventilation on three occasions with a minimum 7-day interval between. Esophageal temperature was maintained within a narrow range (38.5 to 39.0°C). One of three sufentanil CRIs (0.01; 0.025 and 0.05 μg kg-1 minute-1) was randomly selected to be administered on each day of MACISO determinations. On all study days, the individual basal MACISO (MACbasal), the MACISO during one of the infusion rates, and the control one hour post-infusion MAC (MACcontrol) were determined. CRI was continued for 60 minutes before MACISO was determined for each sufentanil dose. The MACISO determinations were performed in duplicate using an electrical stimulus (50V, 50 cycles second-1, 10 ms) applied to the antebrachium. HR, SAP, MAP, DAP, ETCO2, and arterial blood gases were recorded before and after each MACISO determination. Data (mean±SD) were compared by ANOVA followed by Tukey’s test (p<0.05%).MACbasal values were not significantly different (1.64±0.13; 1.61±0.24 and 1.62±0.31%). Sufentanil CRIs (0.01; 0.025 and 0.05 μg kg-1 minute-1) significantly reduced MACISO by 21.4±10.8; 18.5±10.5 and 18.0±13.7%, respectively. There were no significant differences between the MACISO values determined during the CRIs. The MACcontroll values (1.56±0.26; 1.50±0.22 and 1.53±0.26%) were different from MACbasal indicating the possibility of a residual opioid effect after the discontinuation of infusions. HR and blood pressure values increased during infusion of the higher sufentanil CRIs (0.025 and 0.05 μg kg-1 minute-1). The three CRI doses of sufentanil resulted in similar degrees of MACISO reduction in cats, indicating that... (Complete abstract click electronic access below)
Descrição
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Cirurgia, Anestesia animal - Efeito fisiológico, Gato, Isoflurane
Como citar
DESSEN, Marina Regatieri. Efeitos do citrato de sufentanil, administrado em infusão contínua, na concentração alveolar mínima (CAM) de isofluorano em felinos. 2010. 73 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, 2010.