Avaliação da atividade antidepressiva e ansiolítica do óleo essencial de Rosmarinus officinalis L
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Data
2010-01-19
Autores
Lima, Valéria Martins de [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
Adepressão e as desordens de ansiedade são distúrbios psiquiátricos de alta prevalência, cuja falta ou o tratamento inadequado acarretam um impacto negativo expressivo na vida social, física e mental do individuo. Historicamente, depressão e ansiedade são clinicamente consideradas desordens separadas e distintas, predominantemente devido aos diferentes tratamentos utilizados, usualmente os antidepressivos tricíclicos e os benzodiazepínicos, respectivamente. Entretanto, muitos estudos clínicos têm demonstrado uma grande sobreposição entre esses dois estados e vários antidepressivos são também utilizados no tratamento da ansiedade. Porém, mesmo com o arsenal terapêutico disponível, muitos portadores destes transtornos não respondem ao tratamento, a terapêutica efetiva leva algumas semanas para manifestar seus efeitos e estes são muitas vezes acompanhados por efeitos adversos. Neste contexto, as plantas medicinais desempenham um importante papel na busca de novos compostos, mais eficazes e seguros para o tratamento dessas desordens. O objetivo deste trabalho foi investigar a atividade do óleo essencial obtido da espécie Rosmarinus offi.cinalis L. em modelos experimentais clássicos de depressão (Teste do Nado Forçado), transtorno de ansiedade generalizada (Labirinto em Cruz Elevado) e Transtorno Obsessivo Compulsivo (Teste de Esconder Esferas). Os resultados são promissores, pois o óleo essencial demonstrou ser ativo na dose de 500 mglkg no Teste do ado Forçado e no Teste de Esconder Esferas, sem apresentar indícios de alterações sobre o sistema motor no Teste da Barra Giratória. Não foi observada atividade no modelo de ansiedade generalizada. O conjunto de resultados sugere a presença de efeito compatível com atividade sobre a depressão e sobre o transtorno obsessivo compulsivo. A continuidade deste estudo objetivará o esclarecimento do mecanismo de...
Depression and anxiety are psychiatric disorders of high prevalence. Lack or inappropriate treatment has a significant negative impact on person' s social and physical life as well as on mental well-being. Historically, depression and anxiety were considered separated and distinct disorders in the medical concept, due to different approaches usually used for their treatment, such as tricyclic antidepressants and benzodiazepines, respectively. However, many clinical studies have shown a great overlapping between these two states and many antidepressants are also used for the treatment of anxiety. Although a wide range of therapeutic drugs is available, many patients do not respond to the antidepressant treatment. Some weeks are required for an effective therapeutic response and treatment effects are usually accompanied by unwanted side-effects. Thus, attempts in order to find new, more effective and safe treatment options are necessary. ln this perspective, medicinal plants play an important role on the research of new drugs for treatment of these disorders. The objective ofthis paper was to evaluate the effect of essential oil obtained from Rosmarinus officinalis L. in c1assical experimental models of depression (Forced Swimming Test), generalized anxiety disorder (Elevated Plus Maze) and obsessive-compulsive disorder (Marble Burying Test). Our results are promising, such essential oil was active at 500 mglkg in the Forced Swimming Test and in the Marble Burying Test, without impairment upon the motor system, evaluated in the Rota-rod Test. There was no observed activity in the experimental procedure to generalized anxiety. Data analysis suggests the presence of depression and obsessivecompulsive disorder-like effects. The continuity of this study will intend the elucidation of action mechanisms, pharmacokinetic parameters and toxicity of essential oil form Rosmarinus officinalis L.
Depression and anxiety are psychiatric disorders of high prevalence. Lack or inappropriate treatment has a significant negative impact on person' s social and physical life as well as on mental well-being. Historically, depression and anxiety were considered separated and distinct disorders in the medical concept, due to different approaches usually used for their treatment, such as tricyclic antidepressants and benzodiazepines, respectively. However, many clinical studies have shown a great overlapping between these two states and many antidepressants are also used for the treatment of anxiety. Although a wide range of therapeutic drugs is available, many patients do not respond to the antidepressant treatment. Some weeks are required for an effective therapeutic response and treatment effects are usually accompanied by unwanted side-effects. Thus, attempts in order to find new, more effective and safe treatment options are necessary. ln this perspective, medicinal plants play an important role on the research of new drugs for treatment of these disorders. The objective ofthis paper was to evaluate the effect of essential oil obtained from Rosmarinus officinalis L. in c1assical experimental models of depression (Forced Swimming Test), generalized anxiety disorder (Elevated Plus Maze) and obsessive-compulsive disorder (Marble Burying Test). Our results are promising, such essential oil was active at 500 mglkg in the Forced Swimming Test and in the Marble Burying Test, without impairment upon the motor system, evaluated in the Rota-rod Test. There was no observed activity in the experimental procedure to generalized anxiety. Data analysis suggests the presence of depression and obsessivecompulsive disorder-like effects. The continuity of this study will intend the elucidation of action mechanisms, pharmacokinetic parameters and toxicity of essential oil form Rosmarinus officinalis L.
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Produtos naturais, Plantas medicinais, Farmacologia, Medicinal plants
Como citar
LIMA, Valéria Martins de. Avaliação da atividade antidepressiva e ansiolítica do óleo essencial de Rosmarinus officinalis L. 2010. 46 f. Dissertação (mestrado) - Universidade Estadual Paulista, Instituto de Biociências de Botucatu, 2010.