Avaliação da frequência de síndrome metabólica e sua associação na sobrevida de pacientes com doença pulmonar obstrutiva crônica (DPOC)
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Data
2012-02-27
Autores
Zamuner, Amanda Tiago Silva [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
Os pacientes com doença pulmonar crônica (DPOC) síndrome metabólica (SM) podem apresentar risco aumentado de eventos cardiovasculares pela ssociação do processo inflamatório sistêmico próprio da DPOC com os fatores metabólicos e inflamatórios da SM. Entretanto, a associação da SM na sobrevida neste grupo de pacientes ainda não está esclarecida. Foram avaliados 115 pacientes com DPOC leve a muitograve, idade = 64,5 + - 1,21 anos e VEF1- 58,7+ -2,75%. Todos os pacientes da pesquisa foram avaliados no momento inicial por meio de história clínica, exame físico completo, avaliação antropométrica (peso, estatura, IMC e cincunferência abdominal), espirometria pré e pós broncodilatador, oximetria de pulso, teste de caminhada de seis minutos (TC-6), avaliação dispneia, índice BODE e avaliação laboratorial. A presença de SM foi estabelecida pelos critérios de harmonização da SM. Os pacientes foram acompanhados por período de até cinco anos e durante o acompanhamento, foi observado o óbito e a causa de óbito. As causas de óbitos foram avaliadas mediante verificação do prontuário ou de informações dos familiares. A SM esteve presente em 35,6% dos pacientes. Apenas 16,5% dos pacientes não apresentavam nenhum componente diagnóstico da SM. A hipertensão arterial (47,8%) foi o componente mais frequente dentre os componentes analisados. Pacientes com síndrome metabólica apresentaram valores significativamente menores para HDL-c e maiores para as demais variáveis que participam do diagnóstico de SM. Estas diferenças permaneceram mesmo depois de ajustado para o gênero. Com relação à mortalidade em pacientes com DPOC e SM, foi encontrada a frequência de 19,5%. Não houve diferenças de mortalidade e de causa de morte entre os grupos com e sem SM. Foi observada a associação de...
Patients with chronic obstructive pulmonary disease (COPD) and metabolic syndrome (MS) may be at increased risk of cardiovascular events due to the association of systemic inflammation, characteristic of COPD, and inflammatory and metabolic factors of MS. However, the association of MS in survical in this group of patients is still unclear. We evaluated 115 patients from mild to very severe COPD, age = 64,5 +- 1,21 years and FEVI - 58,7 +- 2,75%. All patients were evaluated at baseline by clinical history, phisical examination, anthropometric measurements (weight, height, BMI and waist circumference), pre and post bronchodilator spirometry, pulse oximetry test, six-minute walk (TC-6), dyspnea assessment, BODE index and laboratory evaluation. The presence o MS was evaluated by harmonization MS. Patients were followed for up to five years and during follow-up death and cause of death were observed. The causes of death were assessed by checking the records or information from family members. MS was present in 35,6% of patients. Only 16,5% of patients did not present any diagnostic component of MS. Hypertension (47,8%) was the most common component among the ones analyzed. Patients with metabolic syndrome had significantly lower values for HDL-C and higher for the other variables that participate in the diagnosis of MS. These differences remained even after adjustment for gender. With regard to mortality in COPD patients with MS, found the frequency of 19.5%. There were no differences in mortaslity and causes of death between groups with and without MS. Observed an association of triglycerides with and moratality (HR = 1,58, IC 95%: 1,19-2,11 and p=0,002). Patients with COPD have intermediate prevalence of metabolic syndrome. In addition, there was no association between MS and... (Complete abstract click electronic access below)
Patients with chronic obstructive pulmonary disease (COPD) and metabolic syndrome (MS) may be at increased risk of cardiovascular events due to the association of systemic inflammation, characteristic of COPD, and inflammatory and metabolic factors of MS. However, the association of MS in survical in this group of patients is still unclear. We evaluated 115 patients from mild to very severe COPD, age = 64,5 +- 1,21 years and FEVI - 58,7 +- 2,75%. All patients were evaluated at baseline by clinical history, phisical examination, anthropometric measurements (weight, height, BMI and waist circumference), pre and post bronchodilator spirometry, pulse oximetry test, six-minute walk (TC-6), dyspnea assessment, BODE index and laboratory evaluation. The presence o MS was evaluated by harmonization MS. Patients were followed for up to five years and during follow-up death and cause of death were observed. The causes of death were assessed by checking the records or information from family members. MS was present in 35,6% of patients. Only 16,5% of patients did not present any diagnostic component of MS. Hypertension (47,8%) was the most common component among the ones analyzed. Patients with metabolic syndrome had significantly lower values for HDL-C and higher for the other variables that participate in the diagnosis of MS. These differences remained even after adjustment for gender. With regard to mortality in COPD patients with MS, found the frequency of 19.5%. There were no differences in mortaslity and causes of death between groups with and without MS. Observed an association of triglycerides with and moratality (HR = 1,58, IC 95%: 1,19-2,11 and p=0,002). Patients with COPD have intermediate prevalence of metabolic syndrome. In addition, there was no association between MS and... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Síndrome metabólica
Como citar
ZAMUNER, Amanda Tiago Silva. Avaliação da frequência de síndrome metabólica e sua associação na sobrevida de pacientes com doença pulmonar obstrutiva crônica (DPOC). 2012. 55 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, 2012.