Efeito da hesperidina no perfil lipídico de ratos tratados com dieta acrescida de ácidos graxos saturados
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Data
2008-02-15
Autores
Vinueza Galárraga, Julio César [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
O objetivo deste estudo foi avaliar o efeito da hesperidina na concentração dos lípides sanguíneos em ratos tratados com dieta acrescida de gordura saturada (17%). A hesperidina foi administrada isolada ou associada ao suco de laranja nas dietas dos ratos e após 30 dias de tratamento foram realizadas as análises bioquímicas de colesterol total, HDL-C e triglicérides no soro dos animais. Não foram observadas diferenças estatísticas entre os grupos para as concentrações de colesterol total e triglicérides, como também não houve diferenças no ganho de peso dos animais tratados com hesperidina ou com suco de laranja mais hesperidina. Houve, todavia, uma diminuição significativa no HDL-C com a suplementação da hesperidina (-20%), mas não com o suco isolado ou em associação com a hesperidina. Estes resultados apontam um papel regulador e especifico da hesperidina no metabolismo dos lípides no rato.
The objective of this study was to evaluate the effect of hesperidin on the blood lipids in rats treated with a diet added with saturated fat (17%). Hesperidin was administrated isolated or associated to orange juice in the animal diets, and after 30 days of dietary treatment it was carried out biochemical analysis in the serum of the rats. It was not observed any statistical differences among groups for the concentration of total cholesterol or triglycerides, neither for the weight gained in the rats that had received hesperidin or orange juice. However, it was verified a significant reduction on HDL-C with hesperidin supplementation (-20%), but no effect was observed with orange juice, alone or in association with hesperidin. These results showed a regulatory and specific role for hesperidin on the lipid metabolism of the rat.
The objective of this study was to evaluate the effect of hesperidin on the blood lipids in rats treated with a diet added with saturated fat (17%). Hesperidin was administrated isolated or associated to orange juice in the animal diets, and after 30 days of dietary treatment it was carried out biochemical analysis in the serum of the rats. It was not observed any statistical differences among groups for the concentration of total cholesterol or triglycerides, neither for the weight gained in the rats that had received hesperidin or orange juice. However, it was verified a significant reduction on HDL-C with hesperidin supplementation (-20%), but no effect was observed with orange juice, alone or in association with hesperidin. These results showed a regulatory and specific role for hesperidin on the lipid metabolism of the rat.
Descrição
Palavras-chave
Hesperidina - Tese, Suco de laranja - Teses, Lípides sangüineos - Teses, Rato como animal de laboratorio - Tese
Como citar
VINUEZA GALÁRRAGA, Julio César. Efeito da hesperidina no perfil lipídico de ratos tratados com dieta acrescida de ácidos graxos saturados. 2008. 71 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas, 2008.