Dietary Polydextrose Prevents Inflammatory Bowel Disease in Trinitrobenzenesulfonic Acid Model of Rat Colitis

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dc.contributor.authorWitaicenis, Aline [UNESP]
dc.contributor.authorFruet, Andrea C. [UNESP]
dc.contributor.authorSalem, Leticia [UNESP]
dc.contributor.authorDi Stasi, Luiz C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:49:16Z
dc.date.available2014-05-20T13:49:16Z
dc.date.issued2010-12-01
dc.description.abstractInflammatory bowel disease (IBD) is a multifactorial intestinal disorder that involves interactions among the immune system, genetic susceptibility, and environmental factors, especially the bacterial flora. Polydextrose, a polysaccharide constituted by 90% nondigestible and nonabsorbable soluble fibers, has several physiological effects consistent with those of dietary fibers, including proliferation of colon microflora. Because sulfasalazine presents serious side effects through long-term use at high doses, the aim of the present study was to evaluate the preventative effect of polydextrose on trinitrobenzenesulfonic acid-induced intestinal inflammation and its effects on the intestinal anti-inflammatory activity of sulfasalazine. Results indicated that polydextrose and its association with sulfasalazine present an anti-inflammatory effect that reduces myeloperoxidase activity, counteracts glutathione content, and promotes reductions in lesion extension and colonic weight/length ratio.en
dc.description.affiliationSão Paulo State Univ UNESP, Inst Biosci, Dept Pharmacol, Lab Phytomed, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Inst Biosci, Dept Pharmacol, Lab Phytomed, BR-18618000 Botucatu, SP, Brazil
dc.format.extent1391-1396
dc.identifierhttp://dx.doi.org/10.1089/jmf.2009.0275
dc.identifier.citationJournal of Medicinal Food. New Rochelle: Mary Ann Liebert Inc., v. 13, n. 6, p. 1391-1396, 2010.
dc.identifier.doi10.1089/jmf.2009.0275
dc.identifier.fileWOS000284540800015.pdf
dc.identifier.issn1096-620X
dc.identifier.urihttp://hdl.handle.net/11449/17548
dc.identifier.wosWOS:000284540800015
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc.
dc.relation.ispartofJournal of Medicinal Food
dc.relation.ispartofjcr1.954
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectintestinal inflammationen
dc.subjectirritable bowel diseaseen
dc.subjectprebioticsen
dc.subjectsulfasalazineen
dc.titleDietary Polydextrose Prevents Inflammatory Bowel Disease in Trinitrobenzenesulfonic Acid Model of Rat Colitisen
dc.typeArtigo
dcterms.licensehttp://www.liebertpub.com/reprints/journal-of-medicinal-food/38/
dcterms.rightsHolderMary Ann Liebert Inc.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Farmacologia - IBB