Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits

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dc.contributor.authorPaço, Cristian Durço [UNESP]
dc.contributor.authorVane, Matheus Fachini
dc.contributor.authorAndrade, Rafael Bicarato De [UNESP]
dc.contributor.authorDomingues, Maria Aparecida Custódio [UNESP]
dc.contributor.authorCarvalho, Lidia Raquel De [UNESP]
dc.contributor.authorSantos, Daniela Carvalho Dos [UNESP]
dc.contributor.authorTakahira, Regina Kiomi [UNESP]
dc.contributor.authorMódolo, Norma Sueli Pinheiro [UNESP]
dc.contributor.authorVane, Luiz Antonio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-10-01T13:08:33Z
dc.date.available2014-10-01T13:08:33Z
dc.date.issued2013-12-01
dc.description.abstractPURPOSE: To compare the incidence of endothelial injury after single-dose or continuous propofol infusion in conventional lipid-based emulsion (LE) versus microemulsion (ME). METHODS: Forty-two rabbits (2.5-4.5 Kg) were randomly allocated into seven groups of six animals each: SHAM- surgical treatment alone; Bolus Control Group - 3 mL-intravenous (IV) bolus of saline; Continuous Infusion Control Group - 3 mL- IV bolus of saline followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Bolus LE Propofol Group - IV bolus of LE propofol (3 mg/kg); Bolus ME Propofol Group - IV ME propofol bolus (3 mg/kg); Continuous LE Propofol Group - IV LE propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Continuous ME Propofol Group - IV ME propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min. RESULTS: There were no statistically significant differences between the studied groups in blood pressure, in central venous pressure and in the biochemical profile. No significant differences were found in inflammatory mediators and in tissue analysis between the two emulsions. CONCLUSION: Microemulsion and lipid-based emulsion propofol had similar inflammatory, biochemical and microscopy profiles. Thus, microemulsion propofol can be used as an alternative to lipid-based emulsion propofol.en
dc.description.affiliationSao Paulo State University Botucatu Medical School Postgraduate Program in Anesthesiology
dc.description.affiliationUniversity of Sao Paulo Medical School Division of Anesthesiology
dc.description.affiliationUNESP Botucatu Medical School
dc.description.affiliationUNESP Botucatu Medical School Department of Pathology
dc.description.affiliationUNESP Biosciences of Institute Department of Biostatistics
dc.description.affiliationUNESP Biosciences Institute Department of Pathology
dc.description.affiliationUNESP Veterinary Medicine and Animal Science School
dc.description.affiliationUNESP Botucatu Medical School Department of Anesthesiology
dc.description.affiliationUnespSao Paulo State University Botucatu Medical School Postgraduate Program in Anesthesiology
dc.description.affiliationUnespUNESP Botucatu Medical School
dc.description.affiliationUnespUNESP Botucatu Medical School Department of Pathology
dc.description.affiliationUnespUNESP Biosciences of Institute Department of Biostatistics
dc.description.affiliationUnespUNESP Biosciences Institute Department of Pathology
dc.description.affiliationUnespUNESP Veterinary Medicine and Animal Science School
dc.description.affiliationUnespUNESP Botucatu Medical School Department of Anesthesiology
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent833-841
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502013001200005
dc.identifier.citationActa Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 12, p. 833-841, 2013.
dc.identifier.doi10.1590/S0102-86502013001200005
dc.identifier.fileS0102-86502013001200005.pdf
dc.identifier.issn0102-8650
dc.identifier.lattes8223546475724058
dc.identifier.lattes7802830125342070
dc.identifier.lattes0585723113037140
dc.identifier.orcid0000-0003-3323-4199
dc.identifier.scieloS0102-86502013001200005
dc.identifier.urihttp://hdl.handle.net/11449/109791
dc.identifier.wosWOS:000328649900005
dc.language.isoeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartofActa Cirúrgica Brasileira
dc.relation.ispartofjcr0.933
dc.relation.ispartofsjr0,395
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectAnestheticsen
dc.subjectIntravenousen
dc.subjectPropofolen
dc.subjectSolventsen
dc.subjectInflammationen
dc.subjectMicroscopyen
dc.subjectRabittsen
dc.titleEffects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbitsen
dc.typeArtigo
unesp.author.lattes8223546475724058
unesp.author.lattes7802830125342070
unesp.author.lattes0585723113037140
unesp.author.orcid0000-0003-3323-4199[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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