Zinc sulphate administered by transdermal iontophoresis improves breaking strength of surgical wounds in skin of alloxan-induced diabetic rats

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dc.contributor.authorCassettari, Lucas Langoni [UNESP]
dc.contributor.authorDias, Pedro Colli Rocha [UNESP]
dc.contributor.authorLucchesi, Amanda Natália [UNESP]
dc.contributor.authorde Arruda, Maurício Ferraz
dc.contributor.authorSpadella, César Tadeu [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionIMES-FAFICA
dc.date.accessioned2014-05-27T11:30:06Z
dc.date.available2014-05-27T11:30:06Z
dc.date.issued2013-08-01
dc.description.abstractPurpose: To investigate the effect of zinc sulphate administered by transdermal iontophoresis (TDI) on mechanical resistance of surgical wounds performed in the skin of diabetic rats. Methods: One hundred and sixty male Wistar rats weighing approximately 250g were submitted to an incision surgery at the anterior region of abdomen and randomly distributed into four experimental groups with 40 non-diabetic control animals (G1) and 40 untreated diabetic animals (G2), both without any treatment of incisions; 40 non-diabetic animals (G3) and 40 untreated diabetic animals (G4), both with incisions treated with zinc sulphate, administered for a period of four consecutive days after surgery, in sessions of ten minutes duration, using a continuous-current electrostimulator (Zn + TDI). Each experimental group was further divided into four subgroups with ten rats each to be evaluated on the 4th, 7th, 14th, and 21st day after surgery. In each period were analyzed clinical and laboratory from the animals, and measured the breaking strength and hydroxyproline content (OH-P) of the skin scars. RESULTS: Breaking strength (BS) was significantly reduced (p<0.05) in skin scars of untreated diabetic rats (G2) on the 7th, 14th, and 21st postoperative days when compared to non-diabetic control rats (G1). In contrast, BS in skin scars of non-diabetic and untreated diabetic rats (G3, G4) treated with Zn + TDI showed significant increase (p<0.05) in those periods when compared with their respective controls with untreated incisions. The OH-P content of the scars did not show statistically significant variation in all studied groups at four different times evaluated after surgery. Conclusions: Zinc sulphate administered by transdermal iontophoresis had beneficial effect on the mechanical resistance of scars produced in the skin of diabetic rats. This therapeutic may have potential to reduce the complications observed in surgical wounds of the skin in diabetic subjects, mainly in most vulnerable stages of incisions to dehiscences, leakages and infections.en
dc.description.affiliationSao Paulo State University (UNESP), Botucatu, SP
dc.description.affiliationUNESP, Botucatu, SP
dc.description.affiliationMunicipal Institute of Higher Education IMES-FAFICA, Catanduva, SP
dc.description.affiliationDepartment of Surgery and Orthopedics UNESP, Botucatu, SP
dc.description.affiliationUnespSao Paulo State University (UNESP), Botucatu, SP
dc.description.affiliationUnespUNESP, Botucatu, SP
dc.description.affiliationUnespDepartment of Surgery and Orthopedics UNESP, Botucatu, SP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent601-606
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502013000800008
dc.identifier.citationActa Cirurgica Brasileira, v. 28, n. 8, p. 601-606, 2013.
dc.identifier.doi10.1590/S0102-86502013000800008
dc.identifier.file2-s2.0-84881041244.pdf
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.lattes6223012281302736
dc.identifier.scieloS0102-86502013000800008
dc.identifier.scopus2-s2.0-84881041244
dc.identifier.urihttp://hdl.handle.net/11449/76175
dc.identifier.wosWOS:000322433100008
dc.language.isoeng
dc.relation.ispartofActa Cirúrgica Brasileira
dc.relation.ispartofjcr0.933
dc.relation.ispartofsjr0,395
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAlloxan
dc.subjectDiabetes mellitus
dc.subjectIontophoresis
dc.subjectRats
dc.subjectWound healing
dc.subjectZinc sulfate
dc.subjectglucose
dc.subjectglycosylated hemoglobin
dc.subjecthydroxyproline
dc.subjectinsulin
dc.subjectzinc sulfate
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectcontrolled study
dc.subjectdiabetes mellitus
dc.subjectelectrode
dc.subjectiontophoresis
dc.subjectmale
dc.subjectnonhuman
dc.subjectpostoperative period
dc.subjectrat
dc.subjectskin scar
dc.subjectstrength
dc.subjectsurgical technique
dc.subjectsurgical wound
dc.titleZinc sulphate administered by transdermal iontophoresis improves breaking strength of surgical wounds in skin of alloxan-induced diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/acb/paboutj.htm#04
unesp.author.lattes6223012281302736
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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